RNA Structure and Biophysics
University of Nottingham
We study RNA-mediated disease pathologies at high-resolution.
Research in my lab focuses on determining the role of RNA-protein complexes in establishing viral infection in the cell, looking at viruses such as HIV, Arenaviruses and Flaviviruses.
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We also investigate the consequences of RNA misfolding on cellular health, particularly in rare diseases such as Myotonic Dystrophy.
RNAs are one of the most difficult systems to study, and thus we also develop challenge driven methods to determine RNA structure and dynamics. We recently pioneered Mass Spectrometry guided RNA structure determination and have invented affinity-grid methods for cryo-Electron Microscopy.
Going beyond technology development and discovery research, we also inform the next-generation of RNA-based therapies, such as antivirals and vaccines.